SS-31

SS-31 (Elamipretide) – Mitochondrial Support & Cellular Energy Peptide

• Composition: SS-31 (lyophilized peptide powder)
• Category: Mitochondria-targeting peptide
• Form: Vial with freeze-dried powder
• Research Application: Laboratory research following reconstitution with bacteriostatic water

What is SS-31?

SS-31, also known as Elamipretide or MTP-131, is a synthetic tetrapeptide developed for research into mitochondrial function and cellular energy metabolism.

SS-31 selectively targets the inner mitochondrial membrane, where it interacts with cardiolipin, a phospholipid essential for mitochondrial structure, electron transport, and energy production.

Research suggests that SS-31 may help stabilize mitochondrial membranes, improve bioenergetic efficiency, and reduce excessive oxidative stress under experimental conditions.

Ideal for mitochondrial research, cellular-energy studies, oxidative-stress models, and investigations into age-related mitochondrial decline.

Key Research Findings

Mitochondrial Membrane Support: Research indicates that SS-31 interacts with cardiolipin and may help preserve the structural integrity of the inner mitochondrial membrane.

Cellular Energy Production: Studied for its potential to support efficient electron transport and ATP production.

Oxidative-Stress Regulation: May reduce excessive mitochondrial reactive oxygen species and associated cellular damage in experimental models.

Cellular Resilience: Investigated for its potential to protect mitochondrial function during metabolic, inflammatory, or age-related stress.

Healthy-Aging Research: Mitochondrial decline is associated with aging, making SS-31 relevant to studies of cellular longevity and age-related biological processes.

Mechanism of Action

SS-31 influences several mitochondrial processes involved in cellular energy and resilience, including:

• Cardiolipin Interaction → Supports inner mitochondrial membrane structure and function
• Electron Transport Optimization → May improve mitochondrial respiration and ATP production
• Oxidative-Stress Modulation → Helps limit excessive production of mitochondrial reactive oxygen species
• Cristae Stabilization → Supports the architecture required for efficient energy generation
• Bioenergetic Support → May improve cellular performance under conditions of mitochondrial stress

Research Application

Reconstitute with bacteriostatic water according to the requirements of the applicable laboratory protocol.

The concentration, quantity, and duration should be determined by the specific in-vitro or preclinical research design. Findings from published studies cannot automatically be transferred between different models, formulations, or experimental settings.

The reconstituted solution should be stored refrigerated and handled according to validated laboratory stability procedures.

Storage Instructions

• Store lyophilized material at 2–8 °C (36–46 °F)
• Protect from light and moisture
• Avoid repeated temperature fluctuations
• Do not freeze after reconstitution unless supported by validated stability data
• Follow the product-specific certificate and laboratory protocol

Why Choose SS-31?

SS-31 is designed for advanced research into mitochondrial bioenergetics, membrane stability, oxidative stress, and cellular resilience.

Unlike peptides that primarily target hormonal or growth-related pathways, SS-31 acts directly at the mitochondrial level through its interaction with cardiolipin. This distinctive mechanism makes it particularly relevant for research involving metabolic stress, mitochondrial dysfunction, and age-related cellular changes.

SS-31 remains an investigational compound, and research outcomes vary depending on the experimental model and protocol.

Order SS-31 and explore its potential in advanced mitochondrial, cellular-energy, and healthy-aging research.